{"id":341,"date":"2021-01-08T00:55:45","date_gmt":"2021-01-07T19:55:45","guid":{"rendered":"http:\/\/curesteps.org\/SCI\/?p=341"},"modified":"2021-01-08T00:55:48","modified_gmt":"2021-01-07T19:55:48","slug":"fibroblast-growth-factors-in-the-management-of-spinal-cord-injury","status":"publish","type":"post","link":"http:\/\/curesteps.org\/SCI\/fibroblast-growth-factors-in-the-management-of-spinal-cord-injury\/","title":{"rendered":"Fibroblast growth factors in the management of spinal cord injury"},"content":{"rendered":"\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5742738\/\">Link<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"jcmm13353-abs-0001title\">Abstract<\/h2>\n\n\n\n<p id=\"__p2\">Spinal cord injury (SCI) possesses a significant health and economic burden worldwide. Traumatic&nbsp;SCI&nbsp;is a devastating condition that evolves through two successive stages. Throughout each of these stages, disturbances in ionic homeostasis, local oedema, ischaemia, focal haemorrhage, free radicals stress and inflammatory response were observed. Although there are no fully restorative cures available for&nbsp;SCI&nbsp;patients, various molecular, cellular and rehabilitative therapies, such as limiting local inflammation, preventing secondary cell death and enhancing the plasticity of local circuits in the spinal cord, were described. Current preclinical studies have showed that fibroblast growth factors (FGFs) alone or combination therapies utilizing cell transplantation and biomaterial scaffolds are proven effective for treating&nbsp;SCI&nbsp;in animal models. More importantly, some studies further demonstrated a paucity of clinical transfer usage to promote functional recovery of numerous patients with&nbsp;SCI. In this review, we focus on the therapeutic capacity and pitfalls of the&nbsp;FGF&nbsp;family and its clinical application for treating&nbsp;SCI, including the signalling component of the&nbsp;FGF&nbsp;pathway and the role in the central nervous system, the pathophysiology of&nbsp;SCI&nbsp;and the targets for&nbsp;FGF&nbsp;treatment. We also discuss the challenges and potential for the clinical translation of&nbsp;FGF\u2010based approaches into treatments for&nbsp;SCI.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Link Abstract Spinal cord injury (SCI) possesses a significant health and economic burden worldwide. Traumatic&nbsp;SCI&nbsp;is a devastating condition that evolves through two successive stages. Throughout each of these stages, disturbances in ionic homeostasis, local oedema, ischaemia, focal haemorrhage, free radicals stress and inflammatory response were observed. Although there are no fully restorative cures available for&nbsp;SCI&nbsp;patients, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[22],"class_list":["post-341","post","type-post","status-publish","format-standard","hentry","category-growth-factors","tag-growth-factors"],"_links":{"self":[{"href":"http:\/\/curesteps.org\/SCI\/wp-json\/wp\/v2\/posts\/341","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/curesteps.org\/SCI\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/curesteps.org\/SCI\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/curesteps.org\/SCI\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/curesteps.org\/SCI\/wp-json\/wp\/v2\/comments?post=341"}],"version-history":[{"count":1,"href":"http:\/\/curesteps.org\/SCI\/wp-json\/wp\/v2\/posts\/341\/revisions"}],"predecessor-version":[{"id":342,"href":"http:\/\/curesteps.org\/SCI\/wp-json\/wp\/v2\/posts\/341\/revisions\/342"}],"wp:attachment":[{"href":"http:\/\/curesteps.org\/SCI\/wp-json\/wp\/v2\/media?parent=341"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/curesteps.org\/SCI\/wp-json\/wp\/v2\/categories?post=341"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/curesteps.org\/SCI\/wp-json\/wp\/v2\/tags?post=341"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}